
Yuh-Nung Jan's lab is interested in the basic mechanisms of neural development. Using the relatively simple Drosophila peripheral nervous system (PNS) to discover the genetic program that controls its development, they aim to uncover evolutionarily conserved core programs that control different steps of neural development in animals. Research originated with the earliest steps in neural development (neurogenesis and neuronal cell fate specification) and gradually worked toward later steps (neuronal morphogenesis and the assembly of a functional neuronal circuit). Some highlights of the lab's earlier efforts include the finding of atonal and numb: atonal is the founding member of a family of proneural genes that initiate the development of two major types of sensory neurons used in vision and hearing; numb functions as a cell fate determinant during asymmetric cell division. Numb provided a starting point for the study of asymmetric cell division in Drosophila and vertebrates, which led to considerable insight into the molecular basis of asymmetric cell division. In recent years, the major focus of the lab has shifted to the study of dendrite development and neuronal circuit assembly.
Genetic Control of Dendrite Development in Drosophila
Dendrite arborization patterns are critical determinants of neural circuit formation and influence the type of synaptic or sensory inputs a neuron is able to receive. Moreover, dendrite defects are associated with a variety of known human mental disorders, such as autism. Relatively little is known about the molecular mechanisms that control dendrite development. To use Drosophila genetics to identify core programs that control dendrite development, we developed a simple assay system. We use the fly transgenic technique to express green fluorescent protein (GFP) in the dendritic arborization (da) neurons, a group of sensory neurons with a stereotyped dendritic branching pattern. This allows us to visualize the development of the dendrites of da neurons in the living fly embryos and to use them as an assay system for a genetic dissection of dendrite development. We have made some recent progress:
1. Regulation of dendritic field size and complexity by transcription factors. Transcription factors are important regulators of the size and complexity of dendritic fields, and the logic of their usage is beginning to emerge. In some cases, the "dendritic fate" of a particular neuron might be specified by a single transcription factor. For example, in the Drosophila PNS, the zinc finger–containing protein Hamlet functions as a binary switch between the elaborate multiple-dendrite morphology of the da neuron and the single, unbranched dendrite morphology of the external sensory (es) neuron. In most cases, however, the dendritic fate is determined by the combined action of multiple transcription factors. Drosophila da neurons fall into four distinct morphological classes (I–IV). The selector gene cut is expressed at different levels in the da neurons. Neurons with small and simple dendritic arbors either do not express Cut (class I neurons) or express low levels of Cut (class II). Neurons with more complex dendritic branching patterns and larger dendritic fields (classes III and IV) express higher levels of Cut. Cut levels are a critical determinant of da neuron class-specific dendritic morphologies.
In contrast to Cut, Spineless (Ss), the homolog of the mammalian dioxin receptor, is expressed at similar levels in all da neurons. In ss mutants, different classes of da neurons elaborate dendrites with similar branch numbers and complexities, suggesting that da neurons might reside in a common "ground" state in the absence of ss function. Studies of the epistatic relationship between Cut and Ss indicate that these transcription factors are likely acting in independent pathways to regulate morphogenesis of da neuron dendrites. These findings, together with an analysis of an RNAi (RNA interference) screen that revealed more than 70 transcription factors regulate dendritic arbor development of class I neurons in fly, suggest that complicated networks of transcriptional regulators likely regulate type-specific dendrite arborization patterns.
2. The molecular mechanism for dendritic self-avoidance and tiling. Dendrite-dendrite repulsion can have a profound influence on the size and shape of the dendritic field, as well as the spatial relationship between different dendritic fields. The dendrites of each da neuron show self-avoidance and tend to spread out without crossing over. Class III and class IV da neurons show tiling; i.e., there is little overlap between the dendritic fields of adjacent neurons of the same class because their dendrites show homotypic repulsion. Recently we found that Dscam (Down syndrome cell adhesion molecule), originally identified as axon guidance receptors by Lawrence Zipursky (HHMI, University of California, Los Angeles) and his colleagues, is needed for self-avoidance and contribute to the spreading of dendrites. Without Dscam, the dendrites of each da neuron bundle together or cross over. For the dendritic fields of different neurons to coexist in the same space, they need to express different Dscam isoforms. In contrast, tiling requires some cell surface recognition molecules other than Dscam to mediate the homotypic repulsion. Although the signals that mediate tiling behavior remain elusive, the evolutionarily conserved protein kinase Tricornered (Trc) and the putative adapter protein Furry (Fry) have been identified as important components of the intracellular signaling cascade involved in tiling. In trc or fry mutants, dendrites no longer show their characteristic turning or retracting response when they encounter same-type dendrites.
3. Dendrite-specific developmental regulators. From our mutant screen, we identified a group of dar (dendritic arborization reduction) genes. Mutations of any of the dar genes lead to defective dendritic arbors but normal axonal projections. Thus, studies of dar genes should reveal how axons and dendrites are made differently. We estimate that there may be a total of about 20 dar genes in Drosophila. All five of the dar genes that we have cloned so far have mammalian homologs. Remarkably, three encode components of the secretory pathway. These results reveal the preferential role of endoplasmic reticulum–Golgi trafficking and Golgi outposts in dendrite arborization.
4. The maintenance of dendritic fields. Our genetic screen revealed specific mechanisms that ensure maintenance of dendritic arbors. We found that the tumor-suppressor Warts (Wts), one of two NDR (nuclear Dbf2-related) family kinases in Drosophila (the other being Trc), and the Polycomb group of genes are required for the maintenance of class IV da dendrites. Loss-of-function mutants of any of those genes cause a progressive defect in the maintenance of dendritic tiling, resulting in large gaps in the receptive field. How are establishment and maintenance of dendritic fields coordinated? In Drosophila class IV neurons, the Ste-20–related tumor-suppressor kinase Hippo (Hpo) can directly phosphorylate and regulate both Trc, which functions in the establishment of dendritic tiling, and Wts, which functions in the maintenance of dendritic tiling. How Hpo regulates the transition from establishment to maintenance of dendritic fields remains to be determined.
5. The remodeling of dendritic fields. Drosophila class IV da neurons undergo dramatic remodeling during metamorphosis. Early in the pupal stage, those neurons prune all their dendrites. Later each neuron grows a completely new dendrite for adult function. While the dendrites are being remodeled, the axons stay largely intact. We have begun to identify the molecular mechanisms that control this large-scale, dendrite-specific remodeling.
Extension of Our Drosophila Work to Dendrite Development of Mammalian Central Neurons
The great majority of the genes found to affect Drosophila dendrite development have a mammalian homolog(s). In several cases, we have shown that those homologs (for example, Dasm1, Dar3/Sar1) have similar function in regulating dendrite development in the mammalian central nervous system. We will continue to extend our findings about dendrite development in Drosophila to the mammalian nervous system by studying cultured hippocampal neurons or knockout mice.
Grants from the National Institutes of Health provided partial support for our research.
Moore, A.W., Jan, L.Y., and Jan, Y.N. (2002). hamlet, a binary genetic switch between single and multiple dendrite neuron morphology. Science 297: 1355-1358.
Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112:63-75.
Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2003). Different levels of the homeodomain protein Cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell 112:805-818.
Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., and Jan, Y.N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119:245-256.
Parrish, J.Z., Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20:820-835.
Kuo, C.T., Zhu, S., Younger, S, Jan, L.Y., and Jan, Y.N. (2006). Identification of e2/e3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 51:283-290.
Emoto, K., Parrish, J.Z., Jan, L.Y., and Jan, Y.N. (2006). The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 14:210-213.
Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N. (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127:1253-1264.
Parrish, J.Z., Emoto, K., Jan, L.Y., and Jan, Y.N. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21:956-972.
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Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020 Nov 25; 108(4):640-650.e4. Wang P, Jia Y, Liu T, Jan YN, Zhang W. PMID: 32910893.
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TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 07 03; 11(1):3298. Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN. PMID: 32620747.
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Chloride channels regulate differentiation and barrier functions of the mammalian airway. Elife. 2020 Apr 14; 9. He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. PMID: 32286221.
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Mechanisms of neurite repair. Curr Opin Neurobiol. 2020 08; 63:53-58. Liu HH, Jan YN. PMID: 32278210.
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Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms. Annu Rev Neurosci. 2020 07 08; 43:207-229. Jin P, Jan LY, Jan YN. PMID: 32084327.
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The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes Dev. 2020 02 01; 34(3-4):194-208. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y. PMID: 31919191.
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Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors. Genes Dev. 2019 12 01; 33(23-24):1739-1750. Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN. PMID: 31753914.
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TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 09 04; 8. Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. PMID: 31482844.
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Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31365878.
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Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 07 18; 8. Ye W, Han TW, He M, Jan YN, Jan LY. PMID: 31318330.
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TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. J Neurosci. 2019 09 04; 39(36):7102-7117. Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY. PMID: 31320449.
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Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349. Wang TA, Teo CF, Ã kerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31319050.
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Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 07 09; 28(2):567-579.e4. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31291589.
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TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586.
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Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7. Wang TA, Teo CF, Ã kerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31151773.
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JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. Development. 2019 04 17; 146(8). Zhu S, Chen R, Soba P, Jan YN. PMID: 30936183.
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The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 04 17; 102(2):373-389.e6. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. PMID: 30819546.
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Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. PMID: 30804200.
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Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. PMID: 30622179.
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Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10748-E10757. Kwon MJ, Han MH, Bagley JA, Hyeon DY, Ko BS, Lee YM, Cha IJ, Kim SY, Kim DY, Kim HM, Hwang D, Lee SB, Jan YN. PMID: 30348793.
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Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 06 04; 150(6):773-775. Jan LY, Jan YN. PMID: 29769227.
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Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. PMID: 29563183.
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Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470. Jan YN, Jan LY. PMID: 29469134.
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The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. PMID: 29478917.
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Force-activated ion channels in close-up. Nature. 2018 Feb; 554(7693):469-470. Jan YN, Jan LY. PMID: 32094930.
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Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. PMID: 29382763.
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Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684.
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Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11161-E11169. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. PMID: 29229864.
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Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. PMID: 29212016.
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Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Cell Rep. 2017 Oct 24; 21(4):859-866. Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN. PMID: 29069593.
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Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity. Cell Rep. 2017 Aug 22; 20(8):1855-1866. Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW. PMID: 28834749.
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Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature. 2017 07 06; 547(7661):118-122. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. PMID: 28658211.
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Age-dependent diastolic heart failure in an in vivo Drosophila model. Elife. 2017 03 22; 6. Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN. PMID: 28328397.
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TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18; 93(2):379-393. Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. PMID: 28065648.
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A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles. J Neurosci. 2016 11 02; 36(44):11275-11282. Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN. PMID: 27807168.
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N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels. J Physiol. 2016 11 15; 594(22):6701-6713. Thayer DA, Yang SB, Jan YN, Jan LY. PMID: 27377235.
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In vivo dendrite regeneration after injury is different from dendrite development. Genes Dev. 2016 08 01; 30(15):1776-89. Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN. PMID: 27542831.
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Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7243-8. Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z. PMID: 27298354.
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Phosphorylation of Ã-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495.
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Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron. 2016 Feb 17; 89(4):741-55. Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN. PMID: 26853303.
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Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. PMID: 26549191.
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Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons. PLoS Genet. 2015 Nov; 11(11):e1005642. Lin T, Pan PY, Lai YT, Chiang KW, Hsieh HL, Wu YP, Ke JM, Lee MC, Liao SS, Shih HT, Tang CY, Yang SB, Cheng HC, Wu JT, Jan YN, Lee HH. PMID: 26540204.
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Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel. Cell. 2015 Sep 10; 162(6):1391-403. Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN. PMID: 26359990.
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EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. PMID: 26258683.
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A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. PMID: 26098020.
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Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. PMID: 25961792.
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The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. Elife. 2015 Mar 12; 4. Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN. PMID: 25764303.
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Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3338-43. To TL, Piggott BJ, Makhijani K, Yu D, Jan YN, Shu X. PMID: 25733847.
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Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3547-52. Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY. PMID: 25733897.
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MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 03; 84(5):968-82. Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. PMID: 25456499.
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Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila. Cell Rep. 2014 Nov 20; 9(4):1446-58. Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN. PMID: 25456135.
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Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. Elife. 2014 Oct 30; 3. Zhang W, Yan Z, Li B, Jan LY, Jan YN. PMID: 25358089.
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Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 2014 Sep 01; 28(17):1940-56. Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN. PMID: 25184680.
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A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife. 2014 Jun 30; 3. Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. PMID: 24980701.
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An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. PMID: 24832154.
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Krüppel mediates the selective rebalancing of ion channel expression. Neuron. 2014 May 07; 82(3):537-44. Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW. PMID: 24811378.
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Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7331-6. Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN. PMID: 24799714.
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Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014 Feb 05; 81(3):544-560. Han C, Song Y, Xiao H, Wang D, Franc NC, Jan LY, Jan YN. PMID: 24412417.
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A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating. Neuron. 2013 Dec 04; 80(5):1190-205. Kim WJ, Jan LY, Jan YN. PMID: 24314729.
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Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila. Nat Neurosci. 2014 Jan; 17(1):81-8. Yuan Q, Song Y, Yang CH, Jan LY, Jan YN. PMID: 24241395.
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Subdued, a TMEM16 family Ca²âº-activated Clâ»channel in Drosophila melanogaster with an unexpected role in host defense. Elife. 2013 Nov 05; 2:e00862. Wong XM, Younger S, Peters CJ, Jan YN, Jan LY. PMID: 24192034.
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Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13612-7. Zhang W, Yan Z, Jan LY, Jan YN. PMID: 23898199.
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TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. PMID: 23872594.
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Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. PMID: 23576756.
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Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1482-7. Thayer DA, Jan YN, Jan LY. PMID: 23297202.
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Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431):221-5. Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN. PMID: 23222543.
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Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron. 2012 Dec 06; 76(5):921-30. Ori-McKenney KM, Jan LY, Jan YN. PMID: 23217741.
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TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. PMID: 23021219.
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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. PMID: 22988107.
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Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. PMID: 22884327.
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Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain. J Neurosci. 1994 Apr; 14(4):2408-17. Sheng M, Tsaur ML, Jan YN, Jan LY. PMID: 8158277.
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Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte. Curr Biol. 1994 Apr 01; 4(4):289-300. Clark I, Giniger E, Ruohola-Baker H, Jan LY, Jan YN. PMID: 7922338.
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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature. 1994 Mar 10; 368(6467):144-7. Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY. PMID: 8139656.
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The role of gene cassettes in axis formation during Drosophila oogenesis. Trends Genet. 1994 Mar; 10(3):89-94. Ruohola-Baker H, Jan LY, Jan YN. PMID: 8178370.
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Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. Genomics. 1994 Mar 01; 20(1):56-61. Feder JN, Li L, Jan LY, Jan YN. PMID: 8020957.
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Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell. 1994 Feb 11; 76(3):477-91. Rhyu MS, Jan LY, Jan YN. PMID: 8313469.
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Images of purified Shaker potassium channels. Curr Biol. 1994 Feb 01; 4(2):110-5. Li M, Unwin N, Stauffer KA, Jan YN, Jan LY. PMID: 7953509.
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Neuronal cell fate specification in Drosophila. Curr Opin Neurobiol. 1994 Feb; 4(1):8-13. Jan YN, Jan LY. PMID: 8173329.
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Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore. Nature. 1994 Jan 13; 367(6459):179-82. Lopez GA, Jan YN, Jan LY. PMID: 8114915.
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Genetic control of cell fate specification in Drosophila peripheral nervous system. Annu Rev Genet. 1994; 28:373-93. Jan YN, Jan LY. PMID: 7893132.
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Assembly of potassium channels. Ann N Y Acad Sci. 1993 Dec 20; 707:51-9. Li M, Isacoff E, Jan YN, Jan LY. PMID: 9137541.
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HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell. 1993 Dec 03; 75(5):827-30. Jan YN, Jan LY. PMID: 8252617.
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pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber. Development. 1993 Dec; 119(4):1187-202. Siegel V, Jongens TA, Jan LY, Jan YN. PMID: 8306882.
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The S4-S5 loop contributes to the ion-selective pore of potassium channels. Neuron. 1993 Oct; 11(4):739-49. Slesinger PA, Jan YN, Jan LY. PMID: 8398157.
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Functional gene cassettes in development. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8305-7. Jan YN, Jan LY. PMID: 8378299.
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Presynaptic A-current based on heteromultimeric K+ channels detected in vivo. Nature. 1993 Sep 02; 365(6441):72-5. Sheng M, Liao YJ, Jan YN, Jan LY. PMID: 8361540.
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asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development. 1993 Sep; 119(1):1-17. Brand M, Jarman AP, Jan LY, Jan YN. PMID: 8565817.
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The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Development. 1993 Sep; 119(1):19-29. Jarman AP, Brand M, Jan LY, Jan YN. PMID: 8565819.
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Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 1993 Aug 26; 364(6440):802-6. Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. PMID: 8355805.
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A central role for microtubules in the differentiation of Drosophila oocytes. Development. 1993 Aug; 118(4):1169-80. Theurkauf WE, Alberts BM, Jan YN, Jongens TA. PMID: 8269846.
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A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos. Rouxs Arch Dev Biol. 1993 Aug; 202(6):371-381. Bodmer R, Jan LY, Jan YN. PMID: 28306050.View in: PubMed Mentions:
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atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell. 1993 Jul 02; 73(7):1307-21. Jarman AP, Grau Y, Jan LY, Jan YN. PMID: 8324823.
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Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell. 1993 Jun 04; 73(5):953-65. Ruohola-Baker H, Grell E, Chou TB, Baker D, Jan LY, Jan YN. PMID: 8500182.
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The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1993 Jun; 12(6):2586. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. PMID: 8508781.
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Cell interactions and gene interactions in peripheral neurogenesis. Genes Dev. 1993 May; 7(5):723-33. Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. PMID: 8491375.
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Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993 Mar 11; 362(6416):127-33. Kubo Y, Baldwin TJ, Jan YN, Jan LY. PMID: 7680768.
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Tracing neurons with a kinesin-Ã-galactosidase fusion protein. Rouxs Arch Dev Biol. 1993 Mar; 202(2):112-122. Giniger E, Wells W, Jan LY, Jan YN. PMID: 28305652.View in: PubMed Mentions:
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A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature. 1993 Feb 11; 361(6412):557-61. Crowley TE, Hoey T, Liu JK, Jan YN, Jan LY, Tjian R. PMID: 8429912.
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Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development. 1993 Feb; 117(2):431-40. Giniger E, Jan LY, Jan YN. PMID: 8330518.
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Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila. Development. 1993 Feb; 117(2):441-50. Blochlinger K, Jan LY, Jan YN. PMID: 8330519.
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A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. Mol Cell Biol. 1993 Jan; 13(1):105-13. Feder JN, Jan LY, Jan YN. PMID: 8417318.
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Molecular basis of K+ channel inactivation gating. EXS. 1993; 63:338-51. Isacoff EY, Jan YN, Jan LY. PMID: 8380732.
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deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product. Genes Dev. 1992 Nov; 6(11):2137-51. Bier E, Vaessin H, Younger-Shepherd S, Jan LY, Jan YN. PMID: 1427077.
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deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell. 1992 Sep 18; 70(6):911-22. Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN. PMID: 1525829.
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The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development. 1992 Sep; 116(1):31-40. Rao Y, Bodmer R, Jan LY, Jan YN. PMID: 1483394.
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Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science. 1992 Aug 28; 257(5074):1225-30. Li M, Jan YN, Jan LY. PMID: 1519059.
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The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila. Cell. 1992 Aug 21; 70(4):569-84. Jongens TA, Hay B, Jan LY, Jan YN. PMID: 1380406.
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Neuronal specification. Curr Opin Genet Dev. 1992 Aug; 2(4):608-13. Jan YN, Jan LY. PMID: 1525515.
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The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 1992 Aug; 6(8):1503-17. Rutledge BJ, Zhang K, Bier E, Jan YN, Perrimon N. PMID: 1644292.
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Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron. 1992 Aug; 9(2):271-84. Sheng M, Tsaur ML, Jan YN, Jan LY. PMID: 1497894.
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Studying Drosophila embryogenesis with P-lacZ enhancer trap lines. Rouxs Arch Dev Biol. 1992 Jun; 201(4):194-220. Hartenstein V, Jan YN. PMID: 28305845.View in: PubMed Mentions:
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The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics. 1992 Jun; 131(2):365-75. Bellen HJ, Vaessin H, Bier E, Kolodkin A, D'Evelyn D, Kooyer S, Jan YN. PMID: 1644278.
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Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron. 1992 Jun; 8(6):1055-67. Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY. PMID: 1610565.
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Tracing the roots of ion channels. Cell. 1992 May 29; 69(5):715-8. Jan LY, Jan YN. PMID: 1375539.
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Structural elements involved in specific K+ channel functions. Annu Rev Physiol. 1992; 54:537-55. Jan LY, Jan YN. PMID: 1562183.
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prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 1991 Nov 29; 67(5):941-53. Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN. PMID: 1720353.
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The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1991 Oct; 10(10):2975-83. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. PMID: 1717258.
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Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature. 1991 Sep 05; 353(6339):86-90. Isacoff EY, Jan YN, Jan LY. PMID: 1881453.
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Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation. Genes Dev. 1991 Sep; 5(9):1577-88. Rao Y, Vaessin H, Jan LY, Jan YN. PMID: 1885000.
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Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel. Neuron. 1991 Sep; 7(3):471-83. Baldwin TJ, Tsaur ML, Lopez GA, Jan YN, Jan LY. PMID: 1840649.
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Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell. 1991 Aug 09; 66(3):433-49. Ruohola H, Bremer KA, Baker D, Swedlow JR, Jan LY, Jan YN. PMID: 1907889.
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Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels. Neuron. 1991 Aug; 7(2):327-36. Lopez GA, Jan YN, Jan LY. PMID: 1873032.
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Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 1991 Jul; 5(7):1124-35. Blochlinger K, Jan LY, Jan YN. PMID: 1676691.
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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 1991 Jan 24; 349(6307):305-10. Papazian DM, Timpe LC, Jan YN, Jan LY. PMID: 1846229.
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Genetic and molecular bases of neurogenesis in Drosophila melanogaster. Annu Rev Neurosci. 1991; 14:399-420. Campos-Ortega JA, Jan YN. PMID: 1903242.
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Genes required for specifying cell fates in Drosophila embryonic sensory nervous system. Trends Neurosci. 1990 Dec; 13(12):493-8. Jan YN, Jan LY. PMID: 1703680.
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A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990 Nov; 110(3):661-9. Bodmer R, Jan LY, Jan YN. PMID: 1982429.
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How might the diversity of potassium channels be generated? Trends Neurosci. 1990 Oct; 13(10):415-9. Jan LY, Jan YN. PMID: 1700515.
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Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos. Genes Dev. 1990 Aug; 4(8):1322-31. Blochlinger K, Bodmer R, Jan LY, Jan YN. PMID: 1977661.
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A superfamily of ion channels. Nature. 1990 Jun 21; 345(6277):672. Jan LY, Jan YN. PMID: 1694264.
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Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature. 1990 Jun 07; 345(6275):530-4. Isacoff EY, Jan YN, Jan LY. PMID: 2112229.
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Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development. 1990 Jun; 109(2):425-33. Hay B, Jan LY, Jan YN. PMID: 2119289.
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Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990 May 10; 345(6271):163-7. Rao Y, Jan LY, Jan YN. PMID: 1692392.
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rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 1990 Feb; 4(2):190-203. Bier E, Jan LY, Jan YN. PMID: 2110920.
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Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila. Neuron. 1990 Jan; 4(1):119-27. Schwarz TL, Papazian DM, Carretto RC, Jan YN, Jan LY. PMID: 2310570.
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Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol. 1990; 55:239-45. Vaessin H, Caudy M, Bier E, Jan LY, Jan YN. PMID: 2132818.
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Molecular studies of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1990; 55:9-17. Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY. PMID: 2132867.
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Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11; 58(3):537-44. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB. PMID: 2503252.
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numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 1989 Jul 28; 58(2):349-60. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. PMID: 2752427.
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Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages. Neuron. 1989 Jul; 3(1):21-32. Bodmer R, Carretto R, Jan YN. PMID: 2515889.
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Voltage-sensitive ion channels. Cell. 1989 Jan 13; 56(1):13-25. Jan LY, Jan YN. PMID: 2463091.
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daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell. 1988 Dec 23; 55(6):1061-7. Caudy M, Vässin H, Brand M, Tuma R, Jan LY, Jan YN. PMID: 3203380.
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The determination of sense organs in Drosophila: interaction of scute with daughterless. Rouxs Arch Dev Biol. 1988 Dec; 197(7):419-423. Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 28305749.View in: PubMed Mentions:
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A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell. 1988 Nov 18; 55(4):577-87. Hay B, Jan LY, Jan YN. PMID: 3052853.
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A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J. 1988 Nov; 7(11):3471-7. Katz F, Moats W, Jan YN. PMID: 2463162.
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Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes. Neuron. 1988 Oct; 1(8):659-67. Timpe LC, Jan YN, Jan LY. PMID: 3272184.
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Identification of a component of Drosophila polar granules. Development. 1988 Aug; 103(4):625-40. Hay B, Ackerman L, Barbel S, Jan LY, Jan YN. PMID: 3150351.
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The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev. 1988 Jul; 2(7):843-52. Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 3209070.
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Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature. 1988 Jun 16; 333(6174):629-35. Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN. PMID: 2897632.
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Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science. 1988 May 13; 240(4854):913-6. Bier E, Ackerman L, Barbel S, Jan L, Jan YN. PMID: 3129785.
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Cloning of a probable potassium channel gene from mouse brain. Nature. 1988 Apr 28; 332(6167):837-9. Tempel BL, Jan YN, Jan LY. PMID: 2451788.
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Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature. 1988 Jan 14; 331(6152):137-42. Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448635.
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Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature. 1988 Jan 14; 331(6152):143-5. Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448636.
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Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J Neurosci. 1987 Dec; 7(12):4195-200. Branton WD, Kolton L, Jan YN, Jan LY. PMID: 2826721.
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Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell. 1987 Oct 23; 51(2):293-307. Bodmer R, Barbel S, Sheperd S, Jack JW, Jan LY, Jan YN. PMID: 3117374.
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Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science. 1987 Aug 14; 237(4816):749-53. Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY. PMID: 2441470.
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Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 1987 Aug 14; 237(4816):770-5. Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY. PMID: 2441471.
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Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta. Proc Natl Acad Sci U S A. 1987 May; 84(10):3506-10. Bowers CW, Phillips HS, Lee P, Jan YN, Jan LY. PMID: 3033650.
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Morphological differentiation of the embryonic peripheral neurons in Drosophila. Rouxs Arch Dev Biol. 1987 Feb; 196(2):69-77. Bodmer R, Jan YN. PMID: 28305460.View in: PubMed Mentions:
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Muscle connections between imaginal discs in Drosophila. Dev Biol. 1986 Feb; 113(2):288-94. Dambly-Chaudière C, Ghysen A, Jan YN, Jan LY. PMID: 3081389.
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The LHRH family of peptide messengers in the frog nervous system. Prog Brain Res. 1986; 68:205-15. Branton WD, Phillips HS, Jan YN. PMID: 3550890.
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Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J Neurosci. 1985 Sep; 5(9):2453-64. Jan YN, Ghysen A, Christoph I, Barbel S, Jan LY. PMID: 3928832.
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Selective phosphorylation of cytosol proteins associated with transformation and restoration of normal phenotype in AKR mouse embryo fibroblasts. Cancer Res. 1985 May; 45(5):2170-6. Chakrabarty S, Jan Y, Son J, Miller CA, Brattain MG. PMID: 3872713.
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Segmental determination in Drosophila central nervous system. Cell. 1985 Apr; 40(4):943-8. Ghysen A, Jan LY, Jan YN. PMID: 3886161.
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Some features of peptidergic transmission. Prog Brain Res. 1983; 58:49-59. Jan YN, Jan LY. PMID: 6138814.
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Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:233-45. Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN. PMID: 6327158.
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Peptides in neuronal function: studies using frog autonomic ganglia. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:363-74. Jan YN, Bowers CW, Branton D, Evans L, Jan LY. PMID: 6327165.
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Peptidergic transmission in sympathetic ganglia of the frog. J Physiol. 1982 Jun; 327:219-46. Jan LY, Jan YN. PMID: 6181250.
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Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A. 1982 Apr; 79(8):2700-4. Jan LY, Jan YN. PMID: 6806816.
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Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1982; 1(11):1373-9. Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. PMID: 16453437.
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Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog. Fed Proc. 1981 Sep; 40(11):2560-4. Jan LY, Jan YN. PMID: 6115771.
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Peptidergic transmitters in synaptic boutons of sympathetic ganglia. Nature. 1980 Nov 27; 288(5789):380-2. Jan LY, Jan YN, Brownfield MS. PMID: 6107864.
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Further evidence for peptidergic transmission in sympathetic ganglia. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):5008-12. Jan YN, Jan LY, Kuffler SW. PMID: 6254052.
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A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):4047-51. Wu CF, Ganetzky B, Jan LY, Jan YN, Benzer S. PMID: 211514.
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L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J Physiol. 1976 Oct; 262(1):215-36. Jan LY, Jan YN. PMID: 186587.
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dunce, a mutant of Drosophila deficient in learning. Proc Natl Acad Sci U S A. 1976 May; 73(5):1684-8. Dudai Y, Jan YN, Byers D, Quinn WG, Benzer S. PMID: 818641.
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Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces. J Gen Physiol. 1975 Jul; 66(1):67-95. Cohen RJ, Jan YN, Matricon J, Delbrück M. PMID: 1159403.
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[Bacterial endocarditis in children associated with congenital cardiopathies: clinical aspects and outcome. Apropos of 22 cases]. Arch Fr Pediatr. 1974 Dec; 31(10):955-71. Jan Y, Loth P. PMID: 4463929.
Yuh-Nung Jan earned his undergraduate degree in Physics from National Taiwan University before pursuing a PhD in Biology at California Institute of Technology. He completed subsequent postdoctoral research at both Caltech and Harvard Medical School before joining the Physiology Department and Neuroscience program at UCSF.
Dr. Jan is an elected member of the National Academy of Sciences, Acedemia Sinica Taiwan, and the American Academy of Arts and Sciences, as well as earning a Distinguished Alumni Award from Caltech and a Javits Neuroscience Investigator Award from the National Institutes of Health.