
Most cell types express a variety of ion channels that serve important physiological functions, such as neuronal signaling, regulation of heartbeat and vascular tone, control of ion flow across epithelia, regulation of secretion from exocrine glands, and control of hormone release from endocrine tissues. Molecular identification of these ion channels makes it possible to study one channel type at a time. It enables functional studies of heterologously expressed channels that can be subjected to mutagenesis in order to identify structural elements important for specific aspects of the channel function. It allows the generation of specific probes to examine the localization of channel protein and the mRNA encoding the channel and to elucidate mechanisms for channel regulation in vivo. It also makes it possible to modify the channel gene genetically to test for its physiological roles.
Given the heterogeneity and broad expression of potassium channels and calcium-activated chloride channels, we resorted to performing Drosophila chromosome walk or expression cloning using frog oocytes or axolotl oocytes as the expression system, for the initial molecular identification of founding members of voltage-gated potassium channels (1987), inwardly rectifying potassium channels (1993) and calcium-activated chloride channels (2008). Once these ion channels were molecularly identified, we asked how these channels work, how transmitter actions and second messengers may regulate channel activity, and how these channels fulfill their physiological functions.
One advantage in channel studies is the possibility of examining one channel at a time, with submillisecond resolution, for many seconds, in experimentally determined intracellular and extracellular environments. In addition to conducting biophysical, biochemical, and cell biological studies of channel assembly, trafficking, regulation, and function, we need to learn how these channels are targeted to specific subcellular compartments of a neuron, how they respond dynamically to neuronal activity, and how these channels in turn modulate neuronal signaling.
Potassium Channels
Conserved among eukaryotes and prokaryotes, potassium channels modulate neuronal signaling in the brain and the peripheral nervous system, regulate cell volume and the flow of salt across epithelia, and control heart rate, vascular tone, and the release of hormones such as insulin. Furthermore, they protect neurons and muscles under metabolic stress.
Potassium channel mutations are linked to diseases of the brain (epilepsy, episodic ataxia), ear (deafness), heart (arrhythmia), muscle (myokymia, periodic paralysis), kidney (hypertension), pancreas (hyperinsulinemic hypoglycemia, neonatal diabetes), as well as developmental abnormalities of neural crest-derived tissues (Andersen's syndrome). Not only do mutations that increase or decrease potassium channel activity cause diseases, but alteration of potassium channel expression levels could also have a strong impact. For example, our recent study revealed that increased expression of EAG2 potassium channels in medulloblastoma (MB) facilitates the volume reduction known as premitotic cytoplasmic condensation that is essential for cells to proceed with mitotic cell division, thereby promoting MB cell proliferation and malignant tumor growth. Moreover, midlife obesity involves an increase in ATP-sensitive potassium channel activity in specific hypothalamic neurons known as the pro-opiomelanocortin (POMC) neurons, thereby reducing both the neuronal excitability and the release of peptides crucial for controlling food intake and body weight.
Calcium-Activated Chloride Channels
Calcium-activated chloride channels (CaCCs) also serve a broad range of physiological functions by regulating the electrical potential across the cell membrane and the flow of salt and water across epithelia. In the nervous system, these chloride channels may regulate neuronal excitability and synaptic efficacy. In the exocrine gland, CaCCs regulate secretion. In the smooth muscle, calcium release from the internal store will activate CaCCs, leading to membrane potential changes that open calcium channels to sustain smooth muscle contraction. In the digestive system, TMEM16A in the interstitial cells of Cajal regulates rhythmic contraction of the stomach and intestines. In the airway, TMEM16A is highly expressed in the airway smooth muscle (ASM), and the TMEM16A protein level on the luminal surface of airway epithelia is elevated in asthma models. In such asthma models, newly identified CaCC channel blockers reduce mucin secretion and ASM contraction, suggesting that CaCC blockers may be of therapeutic value. In green algae and plants that lack voltage-gated sodium channels, electric signal generation may depend on CaCCs.
While in most cell types the internal chloride concentration is fairly high, so that, for example, CaCCs could generate action potentials in green algae and provide positive feedback regulation to sustain smooth muscle contraction, most central neurons in the adult brain have lower internal chloride concentration, so that chloride channel activation causes inhibition. The internal chloride level may rise, however, in central neurons that have experienced heightened neuronal activity or have been subjected to pathological conditions such as epilepsy or brain trauma. Hence, not only is CaCC activity regulated by calcium entry through NMDA receptors or voltage-gated calcium channels, but also the nature of the CaCC modulation may vary qualitatively because of alterations of the chloride concentration gradient by excessive neuronal activity.
Having shown that TMEM16A and TMEM16AB give rise to CaCCs in frogs and mammals, we found that a member of the Drosophila TMEM16 family forms CaCCs that are important for host defense. Identifying an evolutionarily distant TMEM16 homolog as a CaCC will aid our structure-function studies of this ion channel, which bears no structural similarity to other channel families.
Other Types of Ion Channels in the TMEM16 Family
It is remarkable that the TMEM16 family of transmembrane proteins with unknown function includes not only channels that permeate negatively charged ions but also closely related channels that permeate positively charged ions. While TMEM16A and TMEM16B give rise to CaCCs that allow chloride ions to go through, TMEM16F forms a small-conductance calcium-activated nonselective cation channel (SCAN) that permeates calcium. TMEM16F is linked to the Scott syndrome, a bleeding disorder arising from a deficiency in calcium-activated lipid scrambling that exposes phosphatidylserine on the surface of blood cells to trigger blood coagulation. We found that mice lacking TMEM16F recapitulate this deficiency in blood coagulation.
Unexpectedly, our study revealed that TMEM16C facilitates the sodium-activated potassium channel activity in small dorsal root ganglion (DRG) neurons to modulate the excitability of these sensory neurons and pain sensitivity. TMEM16C forms a complex with the Slack sodium-activated potassium channel to enhance its sodium sensitivity. Genetic deletion of TMEM16C causes a reduction of Slack protein level and sodium-activated potassium current in nonpeptidergic nociceptive DRG neurons, leading to hyperexcitability of these small DRG neurons and heightened pain sensitivity.
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TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. PMID: 23872594.
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Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore. Nature. 1994 Jan 13; 367(6459):179-82. Lopez GA, Jan YN, Jan LY. PMID: 8114915.
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Genetic control of cell fate specification in Drosophila peripheral nervous system. Annu Rev Genet. 1994; 28:373-93. Jan YN, Jan LY. PMID: 7893132.
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Assembly of potassium channels. Ann N Y Acad Sci. 1993 Dec 20; 707:51-9. Li M, Isacoff E, Jan YN, Jan LY. PMID: 9137541.
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HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell. 1993 Dec 03; 75(5):827-30. Jan YN, Jan LY. PMID: 8252617.
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pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber. Development. 1993 Dec; 119(4):1187-202. Siegel V, Jongens TA, Jan LY, Jan YN. PMID: 8306882.
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The S4-S5 loop contributes to the ion-selective pore of potassium channels. Neuron. 1993 Oct; 11(4):739-49. Slesinger PA, Jan YN, Jan LY. PMID: 8398157.
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Functional gene cassettes in development. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8305-7. Jan YN, Jan LY. PMID: 8378299.
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Presynaptic A-current based on heteromultimeric K+ channels detected in vivo. Nature. 1993 Sep 02; 365(6441):72-5. Sheng M, Liao YJ, Jan YN, Jan LY. PMID: 8361540.
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asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development. 1993 Sep; 119(1):1-17. Brand M, Jarman AP, Jan LY, Jan YN. PMID: 8565817.
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The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Development. 1993 Sep; 119(1):19-29. Jarman AP, Brand M, Jan LY, Jan YN. PMID: 8565819.
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Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 1993 Aug 26; 364(6440):802-6. Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. PMID: 8355805.
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A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos. Rouxs Arch Dev Biol. 1993 Aug; 202(6):371-381. Bodmer R, Jan LY, Jan YN. PMID: 28306050.View in: PubMed Mentions:
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atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell. 1993 Jul 02; 73(7):1307-21. Jarman AP, Grau Y, Jan LY, Jan YN. PMID: 8324823.
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Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell. 1993 Jun 04; 73(5):953-65. Ruohola-Baker H, Grell E, Chou TB, Baker D, Jan LY, Jan YN. PMID: 8500182.
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The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1993 Jun; 12(6):2586. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. PMID: 8508781.
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Cell interactions and gene interactions in peripheral neurogenesis. Genes Dev. 1993 May; 7(5):723-33. Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. PMID: 8491375.
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Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993 Mar 11; 362(6416):127-33. Kubo Y, Baldwin TJ, Jan YN, Jan LY. PMID: 7680768.
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Tracing neurons with a kinesin-Ã-galactosidase fusion protein. Rouxs Arch Dev Biol. 1993 Mar; 202(2):112-122. Giniger E, Wells W, Jan LY, Jan YN. PMID: 28305652.View in: PubMed Mentions:
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A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature. 1993 Feb 11; 361(6412):557-61. Crowley TE, Hoey T, Liu JK, Jan YN, Jan LY, Tjian R. PMID: 8429912.
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Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development. 1993 Feb; 117(2):431-40. Giniger E, Jan LY, Jan YN. PMID: 8330518.
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Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila. Development. 1993 Feb; 117(2):441-50. Blochlinger K, Jan LY, Jan YN. PMID: 8330519.
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Molecular basis of K+ channel inactivation gating. EXS. 1993; 63:338-51. Isacoff EY, Jan YN, Jan LY. PMID: 8380732.
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A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. Mol Cell Biol. 1993 Jan; 13(1):105-13. Feder JN, Jan LY, Jan YN. PMID: 8417318.
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deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product. Genes Dev. 1992 Nov; 6(11):2137-51. Bier E, Vaessin H, Younger-Shepherd S, Jan LY, Jan YN. PMID: 1427077.
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deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell. 1992 Sep 18; 70(6):911-22. Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN. PMID: 1525829.
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The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development. 1992 Sep; 116(1):31-40. Rao Y, Bodmer R, Jan LY, Jan YN. PMID: 1483394.
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Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science. 1992 Aug 28; 257(5074):1225-30. Li M, Jan YN, Jan LY. PMID: 1519059.
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The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila. Cell. 1992 Aug 21; 70(4):569-84. Jongens TA, Hay B, Jan LY, Jan YN. PMID: 1380406.
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Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron. 1992 Aug; 9(2):271-84. Sheng M, Tsaur ML, Jan YN, Jan LY. PMID: 1497894.
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Neuronal specification. Curr Opin Genet Dev. 1992 Aug; 2(4):608-13. Jan YN, Jan LY. PMID: 1525515.
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Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron. 1992 Jun; 8(6):1055-67. Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY. PMID: 1610565.
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Tracing the roots of ion channels. Cell. 1992 May 29; 69(5):715-8. Jan LY, Jan YN. PMID: 1375539.
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Structural elements involved in specific K+ channel functions. Annu Rev Physiol. 1992; 54:537-55. Jan LY, Jan YN. PMID: 1562183.
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Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1992; 57:491-9. Baldwin TJ, Isacoff E, Li M, Lopez GA, Sheng M, Tsaur ML, Yan YN, Jan LY. PMID: 1339685.
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prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 1991 Nov 29; 67(5):941-53. Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN. PMID: 1720353.
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The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1991 Oct; 10(10):2975-83. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. PMID: 1717258.
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Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature. 1991 Sep 05; 353(6339):86-90. Isacoff EY, Jan YN, Jan LY. PMID: 1881453.
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Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation. Genes Dev. 1991 Sep; 5(9):1577-88. Rao Y, Vaessin H, Jan LY, Jan YN. PMID: 1885000.
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Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel. Neuron. 1991 Sep; 7(3):471-83. Baldwin TJ, Tsaur ML, Lopez GA, Jan YN, Jan LY. PMID: 1840649.
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Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell. 1991 Aug 09; 66(3):433-49. Ruohola H, Bremer KA, Baker D, Swedlow JR, Jan LY, Jan YN. PMID: 1907889.
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Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels. Neuron. 1991 Aug; 7(2):327-36. Lopez GA, Jan YN, Jan LY. PMID: 1873032.
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Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 1991 Jul; 5(7):1124-35. Blochlinger K, Jan LY, Jan YN. PMID: 1676691.
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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 1991 Jan 24; 349(6307):305-10. Papazian DM, Timpe LC, Jan YN, Jan LY. PMID: 1846229.
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Genes required for specifying cell fates in Drosophila embryonic sensory nervous system. Trends Neurosci. 1990 Dec; 13(12):493-8. Jan YN, Jan LY. PMID: 1703680.
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A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990 Nov; 110(3):661-9. Bodmer R, Jan LY, Jan YN. PMID: 1982429.
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How might the diversity of potassium channels be generated? Trends Neurosci. 1990 Oct; 13(10):415-9. Jan LY, Jan YN. PMID: 1700515.
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Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos. Genes Dev. 1990 Aug; 4(8):1322-31. Blochlinger K, Bodmer R, Jan LY, Jan YN. PMID: 1977661.
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Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line. Neuron. 1990 Aug; 5(2):221-6. Klaiber K, Williams N, Roberts TM, Papazian DM, Jan LY, Miller C. PMID: 2200450.
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A superfamily of ion channels. Nature. 1990 Jun 21; 345(6277):672. Jan LY, Jan YN. PMID: 1694264.
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Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature. 1990 Jun 07; 345(6275):530-4. Isacoff EY, Jan YN, Jan LY. PMID: 2112229.
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Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development. 1990 Jun; 109(2):425-33. Hay B, Jan LY, Jan YN. PMID: 2119289.
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Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990 May 10; 345(6271):163-7. Rao Y, Jan LY, Jan YN. PMID: 1692392.
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rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 1990 Feb; 4(2):190-203. Bier E, Jan LY, Jan YN. PMID: 2110920.
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Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol. 1990; 55:239-45. Vaessin H, Caudy M, Bier E, Jan LY, Jan YN. PMID: 2132818.
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Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila. Neuron. 1990 Jan; 4(1):119-27. Schwarz TL, Papazian DM, Carretto RC, Jan YN, Jan LY. PMID: 2310570.
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Molecular studies of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1990; 55:9-17. Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY. PMID: 2132867.
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Spider toxins selectively block calcium currents in Drosophila. Neuron. 1989 Dec; 3(6):767-72. Leung HT, Branton WD, Phillips HS, Jan L, Byerly L. PMID: 2642017.
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Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11; 58(3):537-44. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB. PMID: 2503252.
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numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 1989 Jul 28; 58(2):349-60. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. PMID: 2752427.
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Voltage-sensitive ion channels. Cell. 1989 Jan 13; 56(1):13-25. Jan LY, Jan YN. PMID: 2463091.
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daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell. 1988 Dec 23; 55(6):1061-7. Caudy M, Vässin H, Brand M, Tuma R, Jan LY, Jan YN. PMID: 3203380.
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A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell. 1988 Nov 18; 55(4):577-87. Hay B, Jan LY, Jan YN. PMID: 3052853.
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Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes. Neuron. 1988 Oct; 1(8):659-67. Timpe LC, Jan YN, Jan LY. PMID: 3272184.
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Identification of a component of Drosophila polar granules. Development. 1988 Aug; 103(4):625-40. Hay B, Ackerman L, Barbel S, Jan LY, Jan YN. PMID: 3150351.
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The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev. 1988 Jul; 2(7):843-52. Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 3209070.
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Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature. 1988 Jun 16; 333(6174):629-35. Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN. PMID: 2897632.
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Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science. 1988 May 13; 240(4854):913-6. Bier E, Ackerman L, Barbel S, Jan L, Jan YN. PMID: 3129785.
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Cloning of a probable potassium channel gene from mouse brain. Nature. 1988 Apr 28; 332(6167):837-9. Tempel BL, Jan YN, Jan LY. PMID: 2451788.
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Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature. 1988 Jan 14; 331(6152):137-42. Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448635.
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Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature. 1988 Jan 14; 331(6152):143-5. Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448636.
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Ion channels in Drosophila. Annu Rev Physiol. 1988; 50:379-94. Papazian DM, Schwarz TL, Tempel BL, Timpe LC, Jan LY. PMID: 2454072.
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Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J Neurosci. 1987 Dec; 7(12):4195-200. Branton WD, Kolton L, Jan YN, Jan LY. PMID: 2826721.
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The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12. Cell. 1987 Oct 23; 51(2):165-73. Royden CS, Pirrotta V, Jan LY. PMID: 3117373.
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Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell. 1987 Oct 23; 51(2):293-307. Bodmer R, Barbel S, Sheperd S, Jack JW, Jan LY, Jan YN. PMID: 3117374.
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Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science. 1987 Aug 14; 237(4816):749-53. Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY. PMID: 2441470.
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Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 1987 Aug 14; 237(4816):770-5. Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY. PMID: 2441471.
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Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta. Proc Natl Acad Sci U S A. 1987 May; 84(10):3506-10. Bowers CW, Phillips HS, Lee P, Jan YN, Jan LY. PMID: 3033650.
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Gene dosage and complementation analysis of the Shaker locus in Drosophila. J Neurosci. 1987 May; 7(5):1307-17. Timpe LC, Jan LY. PMID: 2437260.
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Muscle connections between imaginal discs in Drosophila. Dev Biol. 1986 Feb; 113(2):288-94. Dambly-Chaudière C, Ghysen A, Jan YN, Jan LY. PMID: 3081389.
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Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J Neurosci. 1985 Sep; 5(9):2453-64. Jan YN, Ghysen A, Christoph I, Barbel S, Jan LY. PMID: 3928832.
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Segmental determination in Drosophila central nervous system. Cell. 1985 Apr; 40(4):943-8. Ghysen A, Jan LY, Jan YN. PMID: 3886161.
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Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:233-45. Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN. PMID: 6327158.
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Some features of peptidergic transmission. Prog Brain Res. 1983; 58:49-59. Jan YN, Jan LY. PMID: 6138814.
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Peptides in neuronal function: studies using frog autonomic ganglia. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:363-74. Jan YN, Bowers CW, Branton D, Evans L, Jan LY. PMID: 6327165.
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Peptidergic transmission in sympathetic ganglia of the frog. J Physiol. 1982 Jun; 327:219-46. Jan LY, Jan YN. PMID: 6181250.
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Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A. 1982 Apr; 79(8):2700-4. Jan LY, Jan YN. PMID: 6806816.
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Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1982; 1(11):1373-9. Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. PMID: 16453437.
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Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog. Fed Proc. 1981 Sep; 40(11):2560-4. Jan LY, Jan YN. PMID: 6115771.
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Peptidergic transmitters in synaptic boutons of sympathetic ganglia. Nature. 1980 Nov 27; 288(5789):380-2. Jan LY, Jan YN, Brownfield MS. PMID: 6107864.
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Further evidence for peptidergic transmission in sympathetic ganglia. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):5008-12. Jan YN, Jan LY, Kuffler SW. PMID: 6254052.
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Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol. 1979 May; 81(2):275-300. Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L, Evans L. PMID: 38256.
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A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):4047-51. Wu CF, Ganetzky B, Jan LY, Jan YN, Benzer S. PMID: 211514.
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L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J Physiol. 1976 Oct; 262(1):215-36. Jan LY, Jan YN. PMID: 186587.
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Ultrastructural localization of rhodopsin in the vertebrate retina. J Cell Biol. 1974 Aug; 62(2):257-73. Jan LY, Revel JP. PMID: 4139160.
Lily Jan earned her undergraduate degree in Physics from National Taiwan University before pursuing a PhD in Biology at California Institute of Technology. She completed subsequent postdoctoral research at both Caltech and Harvard Medical School before joining the Physiology Department and Neuroscience program at UCSF.
Dr. Jan has received numerous accolades including Society of Chinese Bioscientists in America Presidential Award, Edward M. Scolnick Prize in Neuroscience, Wiley Price in Biomedical Sciences, and a Gruber Neuroscience Prize.