Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.
Impact of ketone bodies on age-related inflammation and healthspan extension NIHK99AG058801Jan 1, 2019 - Dec 31, 2020 Role: Principal Investigator
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metab. 2021 Aug 26.Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. PMID: 34473956.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Sci Immunol. 2019 11 15; 4(41).Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. PMID: 31732517.
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 12 03; 30(6):1024-1039.e6.Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. PMID: 31735593.
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 10 05; 550(7674):119-123.Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. PMID: 28953873.
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016 Feb 23; 14(7):1571-1580.Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. PMID: 26876170.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar; 21(3):263-9.Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. PMID: 25686106.
Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr). 2014 Feb; 36(1):199-212.Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. PMID: 23949159.