Delling, Markus, Ph.D.

Assistant Professor, UCSF School of Medicine

PhD in Neurobiology, Centre for Molecular Neurobiology (ZMNH), Hamburg, Germany
MSc in Chemistry and Biochemistry, University of Hamburg, Germany

Featured Publications: 

Delling M*, Indzhykulian AA*, Liu X, Xie T, Corey DP, Clapham DE. Primary Cilia are not Calcium-Responsive Mechanosensors, 2016;531:656-60.

Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia, 2015;4:e11066.

Delling M*, DeCaen PG*, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-4. PMC4112737

DeCaen PG*, Delling M*, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013;504:315-8. PMC4073646

Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 2012;22:1149-62. PMC3397829

Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci USA. 2011;108:18114-9. PMC3207667

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome Nat Commun. 2010;1:38. PMC2928581

Dong X, Cheng X, Mills E, Delling M, Wang F, Kurz T , Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel, Nature. 2008;455:992-6.

Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J. Neurosci. 2008;28,8897-907.

Xu H*, Delling M*, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci USA. 2007;104,18321-6. PMC2084341

Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neurosci. 2006; 9, 628-35

Ramsey, I.S., Delling, M., and Clapham, D.E. An Introduction to TRP Channels. Annu Rev Physiol. 2006;68,619-47

Delling M. and Schachner M. The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells in Lipid Rafts in Biology and Medicine, Humana Press 2004Edited by Mattson, Mark, pp. 113-126

Sytnyk V., Leshchyns’ka I., Dityatev A., Delling M., and Schachner M. NCAM mediates accumulation of synaptic precursor organelles at nascent synapses J. Cell Biol. 2002;159,649-61

Delling, M., Wischmeyer, E., Dityatev, A., Sytnyk, V., Veh, RW., Karschin, A. and Schachner, M. The neural cell adhesion molecule NCAM regulates cell surface delivery of G protein-activated inwardly rectifying potassium channels via lipid rafts. J. Neurosci. 2002;22,7154-64

Niethammer, P*., Delling, M*., Sytnyk, V., Dityatev, A. and Schachner, M. Co-signaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J. Cell Biol. 2002;157,521-532

Markus Delling earned his Masters of Science in Chemistry and Biochemistry from University of Hamburg in Germany before pursuing a PhD in Neurobiology from the Centre for Molecular Neurobiology Hamburg (ZMNH). Afterwards, he spent time as a postdoctoral fellow with the Department of Cardiology at the Boston Children’s Hospital, Harvard Medical School and was a Pediatric Instructor of Cardiology at Boston Children’s Hospital before joining UCSF.