Delling M*, Indzhykulian AA*, Liu X, Xie T, Corey DP, Clapham DE. Primary Cilia are not Calcium-Responsive Mechanosensors, 2016;531:656-60.
Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia, 2015;4:e11066.
Delling M*, DeCaen PG*, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-4. PMC4112737
DeCaen PG*, Delling M*, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013;504:315-8. PMC4073646
Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 2012;22:1149-62. PMC3397829
Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci USA. 2011;108:18114-9. PMC3207667
Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome Nat Commun. 2010;1:38. PMC2928581
Dong X, Cheng X, Mills E, Delling M, Wang F, Kurz T , Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel, Nature. 2008;455:992-6.
Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J. Neurosci. 2008;28,8897-907.
Xu H*, Delling M*, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci USA. 2007;104,18321-6. PMC2084341
Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neurosci. 2006; 9, 628-35
Ramsey, I.S., Delling, M., and Clapham, D.E. An Introduction to TRP Channels. Annu Rev Physiol. 2006;68,619-47
Delling M. and Schachner M. The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells in Lipid Rafts in Biology and Medicine, Humana Press 2004Edited by Mattson, Mark, pp. 113-126
Sytnyk V., Leshchyns’ka I., Dityatev A., Delling M., and Schachner M. NCAM mediates accumulation of synaptic precursor organelles at nascent synapses J. Cell Biol. 2002;159,649-61
Delling, M., Wischmeyer, E., Dityatev, A., Sytnyk, V., Veh, RW., Karschin, A. and Schachner, M. The neural cell adhesion molecule NCAM regulates cell surface delivery of G protein-activated inwardly rectifying potassium channels via lipid rafts. J. Neurosci. 2002;22,7154-64
Niethammer, P*., Delling, M*., Sytnyk, V., Dityatev, A. and Schachner, M. Co-signaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J. Cell Biol. 2002;157,521-532
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Electrophysiological Recordings of the Polycystin Complex in the Primary Cilium of Cultured Mouse IMCD-3 Cell Line. Bio Protoc. 2021 Oct 20; 11(20):e4196. Ha K, Delling M. PMID: 34761068; PMCID: PMC8554804.View in: PubMed Mentions:
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S157-S245. Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. PMID: 34529831.
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The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus. Elife. 2020 11 09; 9. Ha K, Nobuhara M, Wang Q, Walker RV, Qian F, Schartner C, Cao E, Delling M. PMID: 33164752.
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New insights into ion channel-dependent signalling during left-right patterning. J Physiol. 2020 05; 598(9):1741-1752. Tajhya R, Delling M. PMID: 31106399.
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Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330.
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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016 06 30; 7:12109. Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H, Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. PMID: 27357649; PMCID: PMC4931332.
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Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE, Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. PMID: 27007841; PMCID: PMC4851444.
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Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. Doerner JF, Delling M, Clapham DE, Doerner JF, Delling M, Clapham DE. PMID: 26650848; PMCID: PMC4714969.
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Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia. Biophysical Journal. 2014 Jan 1; 106(2):638a. DeCaen DP, Delling DM, Clapham CD. .View in: Publisher Site Mentions:
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Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE, Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. PMID: 24336288; PMCID: PMC4112737.
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Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. DeCaen PG, Delling M, Vien TN, Clapham DE, DeCaen PG, Delling M, Vien TN, Clapham DE. PMID: 24336289; PMCID: PMC4073646.
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA, Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. PMID: 23542377; PMCID: PMC3631666.
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Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE, Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. PMID: 22698280; PMCID: PMC3397829.
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Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE, Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. PMID: 22025699; PMCID: PMC3207667.
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PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome. Biophysical Journal. 2011 Feb 1; 100(3):109a. Wang WX, Dong DX, Shen SD, Dawson DT, Li LX, Zhang ZQ, Cheng CX, Zhang ZY, Weisman WL, Delling DM, Xu XH. .View in: Publisher Site Mentions:
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PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13; 1:38. Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H, Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PMID: 20802798; PMCID: PMC2928581.
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Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem. 2009 Nov 13; 284(46):32040-52. Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H, Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H. PMID: 19638346; PMCID: PMC2797275.
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The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel. Biophysical Journal. 2009 Feb 1; 96(3):266a. Dong DX, Cheng CX, Mills ME, Delling DM, Wang WF, Kurz KT, Xu XH. .View in: Publisher Site Mentions:
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Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis. Biophysical Journal. 2009 Feb 1; 96(3):266a. Wang WX, Dong DX, Chen CS, Shen SD, Liu LM, Mills ME, Cheng CX, Delling DM, Xu XH. .View in: Publisher Site Mentions:
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The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16; 455(7215):992-6. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H, Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. PMID: 18794901; PMCID: PMC4301259.
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Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci. 2008 Sep 03; 28(36):8897-907. Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A, Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. PMID: 18768683; PMCID: PMC4301590.
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Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. Xu H, Delling M, Li L, Dong X, Clapham DE, Xu H, Delling M, Li L, Dong X, Clapham DE. PMID: 17989217; PMCID: PMC2084341.
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Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. Xu H, Delling M, Jun JC, Clapham DE, Xu H, Delling M, Jun JC, Clapham DE. PMID: 16617338.
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An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. Ramsey IS, Delling M, Clapham DE, Ramsey IS, Delling M, Clapham DE. PMID: 16460286.
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The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells. Membrane Microdomain Signaling. 2005 Jan 1; 113-125. Delling DM, Schachner SM. .View in: Publisher Site Mentions:
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Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci. 2004 Oct 20; 24(42):9372-82. Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M, Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. PMID: 15496673; PMCID: PMC6730092.
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Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods. 2003 Nov 30; 130(1):65-73. Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A, Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A. PMID: 14583405.
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Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 2002 Nov 25; 159(4):649-61. Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M, Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M. PMID: 12438412; PMCID: PMC2173095.
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The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci. 2002 Aug 15; 22(16):7154-64. Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M, Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M. PMID: 12177211; PMCID: PMC6757893.
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What can we learn from explanted endovascular devices? Eur J Vasc Endovasc Surg. 2002 Aug; 24(2):117-22. Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H, Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H. PMID: 12389232.
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Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32. Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M, Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M. PMID: 11980923; PMCID: PMC2173281.
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Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol. 1999 Sep 05; 40(3):343-55. Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M, Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. PMID: 10440734.
Markus Delling earned his Masters of Science in Chemistry and Biochemistry from University of Hamburg in Germany before pursuing a PhD in Neurobiology from the Centre for Molecular Neurobiology Hamburg (ZMNH). Afterwards, he spent time as a postdoctoral fellow with the Department of Cardiology at the Boston Children’s Hospital, Harvard Medical School and was a Pediatric Instructor of Cardiology at Boston Children’s Hospital before joining UCSF.