
Michael Stryker's laboratory studies the development and plasticity of the central visual system. Most of his laboratory's effort focuses on the role of neural activity in the primary visual cortex of the mouse, where they have identified a circuit that dramatically enhances activity-dependent plasticity in adult animals. They use 2-photon microscopy and electrophysiology to study genetically identified types of neurons in alert animals.
His laboratory's major interest is the in the mechanisms responsible for the development and plasticity of precise connections within the central nervous system, and particularly in the role of neural activity in this process. Most of the work performed is on the visual cortex of the mouse. In normal development, neural connections to and within the visual cortex are refined to high precision through the action of activity-dependent mechanisms of neural plasticity in combination with specific molecular signals. In experiments, the lab induces activity-dependent plasticity experimentally through manipulations of genetics or experience or by pharmacological or neurophysiological intervention in order to discover what cellular mechanisms and what changes in cortical circuitry are responsible for rapid, long lasting changes in neuronal responses. These changes are analyzed using microelectrode recordings, novel techniques for measurement of optical and metabolic signals related to neural activity, including 2-photon microscopy and intrinsic signal imaging, and anatomical and neurochemical tracing of connections.
Current experimental work in the laboratory focuses on four areas: (a) Understanding the coupling between the physiological and anatomical changes responsible for neuronal plasticity. (b) Understanding the cellular mechanisms of activity-dependent cortical plasticity, primarily through the use of transgenic mice. (c) Understanding the interaction between neural activity and molecular cues in the formation of cortical maps. (d) Understanding the difference between the limited plasticity in the adult brain and the much greater plasticity during critical periods in early life.
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Chance and Choice: Recollections of a life in science. (T. Albright and L. Squire, eds.) The History of Neuroscience in Autobiography. 2020; 11:372-423. Stryker, Michael P. View Publication.
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Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Elife. 2020 07 07; 9. Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, Hasenstaub AR, Stryker MP, Alvarez-Buylla A. PMID: 32633719.
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Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21812-21820. Sun YJ, Espinosa JS, Hoseini MS, Stryker MP. PMID: 31591211.
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Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity. J Neurosci. 2019 09 18; 39(38):7529-7538. Hoseini MS, Rakela B, Flores-Ramirez Q, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. PMID: 31391263.
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Widespread activation of awake mouse cortex by electrical stimulation. Int IEEE EMBS Conf Neural Eng. 2019 Mar; 2019:1113-1117. Dadarlat MC, Sun Y, Stryker MP. PMID: 31363384.View in: PubMed Mentions:
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Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex. J Neurosci. 2019 04 03; 39(14):2635-2648. Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini MS, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. PMID: 30705101.
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Flow stimuli reveal ecologically appropriate responses in mouse visual cortex. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):11304-11309. Dyballa L, Hoseini MS, Dadarlat MC, Zucker SW, Stryker MP. PMID: 30327345.
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Amblyopia: New molecular/pharmacological and environmental approaches. Vis Neurosci. 2018 01; 35:E018. Stryker MP, Löwel S. PMID: 29905118.
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Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment. J Neurophysiol. 2017 07 01; 118(1):131-139. Larimer P, Spatazza J, Stryker MP, Alvarez-Buylla A, Hasenstaub AR. PMID: 28356470.
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Locomotion Enhances Neural Encoding of Visual Stimuli in Mouse V1. J Neurosci. 2017 04 05; 37(14):3764-3775. Dadarlat MC, Stryker MP. PMID: 28264980.
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Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, van Rossum MC. PMID: 28093552.
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Integrating Hebbian and homeostatic plasticity: introduction. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). Fox K, Stryker M. PMID: 28093560.
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Homeostatic plasticity mechanisms in mouse V1. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). Kaneko M, Stryker MP. PMID: 28093561.
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Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex. J Neurosci. 2017 03 29; 37(13):3532-3543. Kaneko M, Fu Y, Stryker MP. PMID: 28258167.
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Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep. 2016 08 02; 16(5):1391-1404. Larimer P, Spatazza J, Espinosa JS, Tang Y, Kaneko M, Hasenstaub AR, Stryker MP, Alvarez-Buylla A. PMID: 27425623.
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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. Elife. 2015 Dec 24; 4. Zembrzycki A, Stocker AM, Leingärtner A, Sahara S, Chou SJ, Kalatsky V, May SR, Stryker MP, O'Leary DD. PMID: 26705332.
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Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps. Neuron. 2015 Sep 23; 87(6):1261-1273. Owens MT, Feldheim DA, Stryker MP, Triplett JW. PMID: 26402608.
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A Neural Circuit That Controls Cortical State, Plasticity, and the Gain of Sensory Responses in Mouse. Cold Spring Harb Symp Quant Biol. 2014; 79:1-9. Stryker MP. PMID: 25948638.
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Allison Doupe: in memoriam. Neuron. 2015 Feb 18; 85(4):667-8. Barondes S, Stryker MP. PMID: 25848665.
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A cortical disinhibitory circuit for enhancing adult plasticity. Elife. 2015 Jan 27; 4:e05558. Fu Y, Kaneko M, Tang Y, Alvarez-Buylla A, Stryker MP. PMID: 25626167.
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Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18339-44. PMID: 25489113.
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Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron. 2014 Oct 22; 84(2):497-510. PMID: 25374364.
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Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion. Neuron. 2014 Jul 16; 83(2):455-466. Lee AM, Hoy JL, Bonci A, Wilbrecht L, Stryker MP, Niell CM. PMID: 25033185.
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Sensory experience during locomotion promotes recovery of function in adult visual cortex. Elife. 2014 Jun 26; 3:e02798. PMID: 24970838.
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Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614.
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A cortical circuit for gain control by behavioral state. Cell. 2014 Mar 13; 156(6):1139-1152. PMID: 24630718.
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1SEP-06 Modeling the dynamical interaction of Hebbian and homeostatic plasticity(1SEP Cooperativity in shaping the nerve cell function,Symposium,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014 Jan 1; 54(supplement1-2):s124. Taro Toyoizumi, Megumi Kaneko, Michael P. Stryker, Kenneth D. Miller. .View in: Publisher Site Mentions:
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Development and plasticity of the primary visual cortex. Neuron. 2012 Jul 26; 75(2):230-49. PMID: 22841309.
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Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012 Apr 04; 32(14):4790-802. PMID: 22492034.
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Harnessing neuroplasticity for clinical applications. Brain. 2011 Jun; 134(Pt 6):1591-609. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. PMID: 21482550.
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Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19026-31. Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K. PMID: 20937865.
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Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5611-6. Sato M, Stryker MP. PMID: 20212164.
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Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010 Feb 26; 327(5969):1145-8. Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. PMID: 20185728.
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Modulation of visual responses by behavioral state in mouse visual cortex. Neuron. 2010 Feb 25; 65(4):472-9. Niell CM, Stryker MP. PMID: 20188652.
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Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex. J Neurosci. 2010 Jan 06; 30(1):81-92. Failor S, Nguyen V, Darcy DP, Cang J, Wendland MF, Stryker MP, McQuillen PS. PMID: 20053890.
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Retinal input instructs alignment of visual topographic maps. Cell. 2009 Oct 02; 139(1):175-85. Triplett JW, Owens MT, Yamada J, Lemke G, Cang J, Stryker MP, Feldheim DA. PMID: 19804762.
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Reversing neurodevelopmental disorders in adults. Neuron. 2008 Dec 26; 60(6):950-60. Ehninger D, Li W, Fox K, Stryker MP, Silva AJ. PMID: 19109903.
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Cortical map formation: Molecular cues and structured neural activity cooperate to organize the topographic map in developing visual cortex. International Journal of Developmental Neuroscience. 2008 Dec 1; 26(8):828. Michael Stryker. .View in: Publisher Site Mentions:
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Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus. J Neurosci. 2008 Oct 22; 28(43):11015-23. Cang J, Wang L, Stryker MP, Feldheim DA. PMID: 18945909.
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Delayed plasticity of inhibitory neurons in developing visual cortex. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16797-802. Gandhi SP, Yanagawa Y, Stryker MP. PMID: 18940923.
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Distinctive features of adult ocular dominance plasticity. J Neurosci. 2008 Oct 08; 28(41):10278-86. Sato M, Stryker MP. PMID: 18842887.
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Highly selective receptive fields in mouse visual cortex. J Neurosci. 2008 Jul 23; 28(30):7520-36. Niell CM, Stryker MP. PMID: 18650330.
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Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron. 2008 Jun 12; 58(5):673-80. Kaneko M, Stellwagen D, Malenka RC, Stryker MP. PMID: 18549780.
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On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli. J Neurophysiol. 2008 May; 99(5):2496-509. Sharpee TO, Miller KD, Stryker MP. PMID: 18353910.
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TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nat Neurosci. 2008 Apr; 11(4):497-504. Kaneko M, Hanover JL, England PM, Stryker MP. PMID: 18311133.
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Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity. Neuron. 2008 Feb 28; 57(4):511-23. Cang J, Niell CM, Liu X, Pfeiffenberger C, Feldheim DA, Stryker MP. PMID: 18304481.
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On and off domains of geniculate afferents in cat primary visual cortex. Nat Neurosci. 2008 Jan; 11(1):88-94. Jin JZ, Weng C, Yeh CI, Gordon JA, Ruthazer ES, Stryker MP, Swadlow HA, Alonso JM. PMID: 18084287.
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Intrinsic ON responses of the retinal OFF pathway are suppressed by the ON pathway. J Neurosci. 2006 Nov 15; 26(46):11857-69. RenterÃa RC, Tian N, Cang J, Nakanishi S, Stryker MP, Copenhagen DR. PMID: 17108159.
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Sleep does not enhance the recovery of deprived eye responses in developing visual cortex. Neuroscience. 2006 Dec; 143(3):815-26. Dadvand L, Stryker MP, Frank MG. PMID: 17000056.
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A combination of ephrin-As and neural activity is required for visual system mapping. Developmental Biology. 2006 Jul 1; 295(1):340. David Feldheim, Cory Pfeiffenberger, Jianhua Cang, Michael Stryker. .View in: Publisher Site Mentions:
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Adaptive filtering enhances information transmission in visual cortex. Nature. 2006 Feb 23; 439(7079):936-42. Sharpee TO, Sugihara H, Kurgansky AV, Rebrik SP, Stryker MP, Miller KD. PMID: 16495990.
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Integrated semiconductor optical sensors for chronic, minimally-invasive imaging of brain function. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:1025-8. Lee TT, Levi O, Cang J, Kaneko M, Stryker MP, Smith SJ, Shenoy KV, Harris JS. PMID: 17946016.
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Development of precise maps in visual cortex requires patterned spontaneous activity in the retina. Neuron. 2005 Dec 08; 48(5):797-809. Cang J, RenterÃa RC, Kaneko M, Liu X, Copenhagen DR, Stryker MP. PMID: 16337917.
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Ephrin-as guide the formation of functional maps in the visual cortex. Neuron. 2005 Nov 23; 48(4):577-89. Cang J, Kaneko M, Yamada J, Woods G, Stryker MP, Feldheim DA. PMID: 16301175.
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Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) autophosphorylation. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16438-42. Taha SA, Stryker MP. PMID: 16260732.
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Fine functional organization of auditory cortex revealed by Fourier optical imaging. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13325-30. Kalatsky VA, Polley DB, Merzenich MM, Schreiner CE, Stryker MP. PMID: 16141342.
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Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse. Vis Neurosci. 2005 Sep-Oct; 22(5):685-91. Cang J, Kalatsky VA, Löwel S, Stryker MP. PMID: 16332279.
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An eye-opening experience. Nat Neurosci. 2005 Jan; 8(1):9-10. Gandhi SP, Cang J, Stryker MP. PMID: 15622410.
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Molecular substrates of plasticity in the developing visual cortex. Prog Brain Res. 2005; 147:103-14. Taha SA, Stryker MP. PMID: 15581700.
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Columnar architecture sculpted by GABA circuits in developing cat visual cortex. Science. 2004 Mar 12; 303(5664):1678-81. Hensch TK, Stryker MP. PMID: 15017001.
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Probing feature selectivity of neurons in primary visual cortex with natural stimuli. Proc SPIE Int Soc Opt Eng. 2004; (5467):212-222. Sharpee T, Sugihara H, Kurgansky AV, Rebrik S, Stryker MP, Miller KD. PMID: 18633451.View in: PubMed Mentions:
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Environmental benefits of implementing alternative energy technologies in developing countries. Applied Energy. 2003 Sep 1; 76(1-3):89-100. B Buran, L Butler, A Currano, E Smith, W Tung, K Cleveland, C Buxton, D Lam, T Obler, S Rais-Bahrami, M Stryker, K Herold. .View in: Publisher Site Mentions:
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New paradigm for optical imaging: temporally encoded maps of intrinsic signal. Neuron. 2003 May 22; 38(4):529-45. Kalatsky VA, Stryker MP. PMID: 12765606.
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Substrates of Rapid Plasticity in Developing Visual Cortex. The Neural Basis of Early Vision. 2003 Jan 1; 77-77. Michael P. Stryker. .View in: Publisher Site Mentions:
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Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology. 2002 Nov; 27(5):869-73. Frank MG, Stryker MP, Tecott LH. PMID: 12431861.
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Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity. Neuron. 2002 Oct 24; 36(3):483-91. Taha S, Hanover JL, Silva AJ, Stryker MP. PMID: 12408850.
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Rapid ocular dominance plasticity requires cortical but not geniculate protein synthesis. Neuron. 2002 Apr 25; 34(3):425-36. Taha S, Stryker MP. PMID: 11988173.
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The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons. Neuron. 2001 Aug 16; 31(3):409-20. Pham TA, Rubenstein JL, Silva AJ, Storm DR, Stryker MP. PMID: 11516398.
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TrkB-like immunoreactivity is present on geniculocortical afferents in layer IV of kitten primary visual cortex. J Comp Neurol. 2001 Aug 06; 436(4):391-8. Silver MA, Stryker MP. PMID: 11447584.
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Rapid anatomical plasticity of horizontal connections in the developing visual cortex. J Neurosci. 2001 May 15; 21(10):3476-82. Trachtenberg JT, Stryker MP. PMID: 11331376.
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Factors shaping the corpus callosum. J Comp Neurol. 2001 May 14; 433(4):437-40. Stryker MP, Antonini A. PMID: 11304709.
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Sleep enhances plasticity in the developing visual cortex. Neuron. 2001 Apr; 30(1):275-87. Frank MG, Issa NP, Stryker MP. PMID: 11343661.
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Neuroscience. Drums keep pounding a rhythm in the brain. Science. 2001 Feb 23; 291(5508):1506-7. Stryker MP. PMID: 11234083.
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Emergence of ocular dominance columns in cat visual cortex by 2 weeks of age. J Comp Neurol. 2001 Feb 05; 430(2):235-49. Crair MC, Horton JC, Antonini A, Stryker MP. PMID: 11135259.
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Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. Neuroscience. 2001; 108(4):569-85. Silver MA, Fagiolini M, Gillespie DC, Howe CL, Frank MG, Issa NP, Antonini A, Stryker MP. PMID: 11738495.
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Neurotrophin-4/5 alters responses and blocks the effect of monocular deprivation in cat visual cortex during the critical period. J Neurosci. 2000 Dec 15; 20(24):9174-86. Gillespie DC, Crair MC, Stryker MP. PMID: 11124995.
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Spatial frequency maps in cat visual cortex. J Neurosci. 2000 Nov 15; 20(22):8504-14. Issa NP, Trepel C, Stryker MP. PMID: 11069958.
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Distributions of synaptic vesicle proteins and GAD65 in deprived and nondeprived ocular dominance columns in layer IV of kitten primary visual cortex are unaffected by monocular deprivation. J Comp Neurol. 2000 Jul 10; 422(4):652-64. Silver MA, Stryker MP. PMID: 10861531.
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Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron. 2000 Apr; 26(1):233-45. Xu B, Zang K, Ruff NL, Zhang YA, McConnell SK, Stryker MP, Reichardt LF. PMID: 10798407.
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Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex. Science. 2000 Mar 17; 287(5460):2029-32. Trachtenberg JT, Trepel C, Stryker MP. PMID: 10720332.
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Erratum to âA method for measuring colocalization of presynaptic markers with anatomically labeled axons using double label immunofluorescence and confocal microscopyâ. Journal of Neuroscience Methods. 2000 Mar 1; 96(1):87. Michael A Silver, Michael P Stryker. .View in: Publisher Site Mentions:
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A method for measuring colocalization of presynaptic markers with anatomically labeled axons using double label immunofluorescence and confocal microscopy. J Neurosci Methods. 2000 Jan 15; 94(2):205-15. Silver MA, Stryker MP. PMID: 10661840.
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Synaptic density in geniculocortical afferents remains constant after monocular deprivation in the cat. J Neurosci. 1999 Dec 15; 19(24):10829-42. Silver MA, Stryker MP. PMID: 10594065.
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Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. J Neurosci. 1999 Nov 15; 19(22):RC40. Hanover JL, Huang ZJ, Tonegawa S, Stryker MP. PMID: 10559430.
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Hospital merger leaves clinical science intact. Nature. 1999 Oct 28; 401(6756):842. Stryker MP, Basbaum A, DeFranco T, Herskowitz I, Yamamoto K. PMID: 10553895.
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The critical period for ocular dominance plasticity in the Ferret's visual cortex. J Neurosci. 1999 Aug 15; 19(16):6965-78. Issa NP, Trachtenberg JT, Chapman B, Zahs KR, Stryker MP. PMID: 10436053.
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Anatomical correlates of functional plasticity in mouse visual cortex. J Neurosci. 1999 Jun 01; 19(11):4388-406. Antonini A, Fagiolini M, Stryker MP. PMID: 10341241.
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Sensory maps on the move. Science. 1999 May 07; 284(5416):925-6. Stryker MP. PMID: 10357679.
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Development and organization of ocular dominance bands in primary visual cortex of the sable ferret. J Comp Neurol. 1999 May 03; 407(2):151-65. Ruthazer ES, Baker GE, Stryker MP. PMID: 10213088.
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Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited. Neuron. 1999 Feb; 22(2):375-81. Hata Y, Tsumoto T, Stryker MP. PMID: 10069342.
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CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period. Neuron. 1999 Jan; 22(1):63-72. Pham TA, Impey S, Storm DR, Stryker MP. PMID: 10027290.
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Morphology of single geniculocortical afferents and functional recovery of the visual cortex after reverse monocular deprivation in the kitten. J Neurosci. 1998 Dec 01; 18(23):9896-909. Antonini A, Gillespie DC, Crair MC, Stryker MP. PMID: 9822746.
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Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20; 282(5393):1504-8. Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. PMID: 9822384.
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Effect of sensory disuse on geniculate afferents to cat visual cortex. Vis Neurosci. 1998 May-Jun; 15(3):401-9. Antonini A, Stryker MP. PMID: 9685193.
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Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J Neurosci. 1998 Mar 15; 18(6):2108-17. Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MP. PMID: 9482797.
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The role of visual experience in the development of columns in cat visual cortex. Science. 1998 Jan 23; 279(5350):566-70. Crair MC, Gillespie DC, Stryker MP. PMID: 9438851.
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Relationship between the ocular dominance and orientation maps in visual cortex of monocularly deprived cats. Neuron. 1997 Aug; 19(2):307-18. Crair MC, Ruthazer ES, Gillespie DC, Stryker MP. PMID: 9292721.
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Dendritic development of retinal ganglion cells after prenatal intracranial infusion of tetrodotoxin. Vis Neurosci. 1997 Jul-Aug; 14(4):779-88. Campbell G, Ramoa AS, Stryker MP, Shatz CJ. PMID: 9279005.
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Ocular dominance peaks at pinwheel center singularities of the orientation map in cat visual cortex. J Neurophysiol. 1997 Jun; 77(6):3381-5. Crair MC, Ruthazer ES, Gillespie DC, Stryker MP. PMID: 9212282.
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The role of activity in the development of long-range horizontal connections in area 17 of the ferret. J Neurosci. 1996 Nov 15; 16(22):7253-69. Ruthazer ES, Stryker MP. PMID: 8929433.
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Development of orientation preference maps in ferret primary visual cortex. J Neurosci. 1996 Oct 15; 16(20):6443-53. Chapman B, Stryker MP, Bonhoeffer T. PMID: 8815923.
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Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron. 1996 Sep; 17(3):491-9. Gordon JA, Cioffi D, Silva AJ, Stryker MP. PMID: 8816712.
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Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex. J Physiol. 1996 Jul 15; 494 ( Pt 2):519-27. Ruthazer ES, Gillespie DC, Dawson TM, Snyder SH, Stryker MP. PMID: 8842009.
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Plasticity of geniculocortical afferents following brief or prolonged monocular occlusion in the cat. J Comp Neurol. 1996 May 20; 369(1):64-82. Antonini A, Stryker MP. PMID: 8723703.
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Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse. J Neurosci. 1996 May 15; 16(10):3274-86. Gordon JA, Stryker MP. PMID: 8627365.
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Ocular dominance plasticity under metabotropic glutamate receptor blockade. Science. 1996 Apr 26; 272(5261):554-7. Hensch TK, Stryker MP. PMID: 8614806.
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Neuroscience. Growth through learning. Nature. 1995 May 25; 375(6529):277-8. Stryker MP. PMID: 7753186.
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Control of thalamocortical afferent rearrangement by postsynaptic activity in developing visual cortex. Science. 1994 Sep 16; 265(5179):1732-5. Hata Y, Stryker MP. PMID: 8085163.
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Editorial overview. Current Opinion in Neurobiology. 1994 Aug 1; 4(4):471-473. A.J. Hudspeth, Michael P. Stryker. .View in: Publisher Site Mentions:
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COMPLEXITY MAPS REVEAL CLUSTERS IN NEURONAL ARBORIZATIONS. Fractals. 1994 Jun 1; 02(02):297-301. B. DUBUC, S. W. ZUCKER, M. P. STRYKER. .View in: Publisher Site Mentions:
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Precise development from imprecise rules. Science. 1994 Mar 04; 263(5151):1244-5. Stryker MP. PMID: 8122106.
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Development of orientation selectivity in ferret visual cortex and effects of deprivation. J Neurosci. 1993 Dec; 13(12):5251-62. Chapman B, Stryker MP. PMID: 8254372.
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Development of individual geniculocortical arbors in cat striate cortex and effects of binocular impulse blockade. J Neurosci. 1993 Aug; 13(8):3549-73. Antonini A, Stryker MP. PMID: 8340819.
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Rapid remodeling of axonal arbors in the visual cortex. Science. 1993 Jun 18; 260(5115):1819-21. Antonini A, Stryker MP. PMID: 8511592.
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Amblyopia induced by anisometropia without shrinkage of ocular dominance columns in human striate cortex. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5494-8. Horton JC, Stryker MP. PMID: 8390668.
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Neurobiology. Elements of visual perception. Nature. 1992 Nov 26; 360(6402):301-2. Stryker MP. PMID: 1448145.
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Origin of orientation tuning in the visual cortex. Curr Opin Neurobiol. 1992 Aug; 2(4):498-501. Chapman B, Stryker MP. PMID: 1525548.
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Neurobiology. Temporal associations. Nature. 1991 Nov 14; 354(6349):108-9. Stryker MP. PMID: 1944584.
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Seeing the whole picture. Curr Biol. 1991 Aug; 1(4):252-3. Stryker MP. PMID: 15336135.
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Neuroscience. Cuddling up in the dark. Nature. 1991 Jun 13; 351(6327):526. Stryker MP. PMID: 2046763.
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Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex. J Neurosci. 1991 May; 11(5):1347-58. Chapman B, Zahs KR, Stryker MP. PMID: 2027051.
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Development of Orientation-Specific Neuronal Responses in Ferret Primary Visual Cortex. The Changing Visual System. 1991 Jan 1; 375-377. Barbara Chapman, Michael P. Stryker. .View in: Publisher Site Mentions:
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Retinofugal fibres change conduction velocity and diameter between the optic nerve and tract in ferrets. Nature. 1990 Mar 22; 344(6264):342-5. Baker GE, Stryker MP. PMID: 2314474.
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Experimental and theoretical studies of the organization of afferents to single orientation columns in visual cortex. Cold Spring Harb Symp Quant Biol. 1990; 55:515-27. Stryker MP, Chapman B, Miller KD, Zahs KR. PMID: 2132835.
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Summary: the brain in 1990. Cold Spring Harb Symp Quant Biol. 1990; 55:1049-67. Stryker MP. PMID: 1983440.
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Ocular dominance column development: analysis and simulation. Science. 1989 Aug 11; 245(4918):605-15. Miller KD, Keller JB, Stryker MP. PMID: 2762813.
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Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):5183-7. Miller KD, Chapman B, Stryker MP. PMID: 2567996.
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Cortical physiology. Is grandmother an oscillation? Nature. 1989 Mar 23; 338(6213):297-8. Stryker MP. PMID: 2922058.
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Organization of primary visual cortex (area 17) in the ferret. J Comp Neurol. 1988 Dec 08; 278(2):157-80. Law MI, Zahs KR, Stryker MP. PMID: 3068264.
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Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature. 1988 Dec 01; 336(6198):468-71. Sretavan DW, Shatz CJ, Stryker MP. PMID: 2461517.
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Prenatal tetrodotoxin infusion blocks segregation of retinogeniculate afferents. Science. 1988 Oct 07; 242(4875):87-9. Shatz CJ, Stryker MP. PMID: 3175636.
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Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited. Proc Natl Acad Sci U S A. 1988 May; 85(10):3623-7. Reiter HO, Stryker MP. PMID: 3285347.
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Segregation of ON and OFF afferents to ferret visual cortex. J Neurophysiol. 1988 May; 59(5):1410-29. Zahs KR, Stryker MP. PMID: 3385467.
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Network model of ocular dominance column formation: Analytical results. Neural Networks. 1988 Jan 1; 1:266. K.D Miller, J.B. Keller, M.P. Stryker. .View in: Publisher Site Mentions:
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Network model of ocular dominance column formation: Computational results. Neural Networks. 1988 Jan 1; 1:267. K.D. Miller, M.P. Stryker, J.B. Keller. .View in: Publisher Site Mentions:
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Variability in hand surface representations in areas 3b and 1 in adult owl and squirrel monkeys. J Comp Neurol. 1987 Apr 08; 258(2):281-96. Merzenich MM, Nelson RJ, Kaas JH, Stryker MP, Jenkins WM, Zook JM, Cynader MS, Schoppmann A. PMID: 3584541.
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Anesthetic state does not affect the map of the hand representation within area 3b somatosensory cortex in owl monkey. J Comp Neurol. 1987 Apr 08; 258(2):297-303. Stryker MP, Jenkins WM, Merzenich MM. PMID: 3584542.
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Ocular dominance shift in kitten visual cortex caused by imbalance in retinal electrical activity. Nature. 1986 Nov 13-19; 324(6093):154-6. Chapman B, Jacobson MD, Reiter HO, Stryker MP. PMID: 3785380.
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Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex. J Neurosci. 1986 Aug; 6(8):2117-33. Stryker MP, Harris WA. PMID: 3746403.
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The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures. Brain Res. 1986 Mar 12; 368(1):170-3. Levy RM, Fields HL, Stryker MP, Heinricher MM. PMID: 3955357.
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Cortical activity blockade prevents ocular dominance plasticity in the kitten visual cortex. Exp Brain Res. 1986; 65(1):182-8. Reiter HO, Waitzman DM, Stryker MP. PMID: 3803504.
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The projection of the visual field onto the lateral geniculate nucleus of the ferret. J Comp Neurol. 1985 Nov 08; 241(2):210-24. Zahs KR, Stryker MP. PMID: 4067015.
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Intrinsic projections within visual cortex: evidence for orientation-specific local connections. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):935-9. Matsubara J, Cynader M, Swindale NV, Stryker MP. PMID: 3856241.
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Video and scanning microdensitometer-based imaging systems in autoradiographic densitometry. J Neurosci Methods. 1984 Jun; 11(2):89-100. Ramm P, Kulick JH, Stryker MP, Frost BJ. PMID: 6482503.
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Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol. 1984 Apr 20; 224(4):591-605. Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Schoppmann A, Zook JM. PMID: 6725633.
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On and off sublaminae in the lateral geniculate nucleus of the ferret. J Neurosci. 1983 Oct; 3(10):1943-51. Stryker MP, Zahs KR. PMID: 6619918.
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Studies of nuclear magnetic resonance imaging and regional cerebral glucose metabolism in acute cerebral ischemia: possible mechanism of opiate antagonist therapeutic activity. Life Sci. 1983; 33 Suppl 1:763-8. Levy RM, Stryker M, Hosobuchi Y. PMID: 6664252.
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Role of visual afferent activity in the development of ocular dominance columns. Neurosci Res Program Bull. 1982 Apr; 20(4):540-9. Stryker MP. PMID: 6811966.
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Physiological evidence that the 2-deoxyglucose method reveals orientation columns in cat visual cortex. Nature. 1981 Oct 15-21; 293(5833):574-6. Schoppmann A, Stryker MP. PMID: 7290190.
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With select illustrations created for this book by. Behavioral Neuroscience. 1980 Jan 1; ii. Frank Armitage, Jay Angevine, Elliott Blass, David Cohen, Edward Evarts, Michael Gabriel, William Greenough, John Harvey, Bartley Hoebel, Robert Jensen, Leonard Kitzes, Rodolfo Llinas, Horace Loh, Andras Pellionisz, Lewis Petrinovich, Jon Sassin, David Segal, Kenneth Simansky, Larry Squire, Arnold Starr, Maurice B. Sterman, Michael Stryker, Timothy Teyler, Richard Thompson, Roderick van Buskirk, E. Leong Way, Richard Whalen, Pauline Yahr. .View in: Publisher Site Mentions:
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Postnatal development of ocular dominance columns in layer IV of the cat's visual cortex and the effects of monocular deprivation. Arch Ital Biol. 1978 Sep; 116(3-4):420-6. Stryker MP. PMID: 749724.
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Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation. J Physiol. 1978 Aug; 281:267-83. Shatz CJ, Stryker MP. PMID: 702379.
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Physiological consequences for the cat's visual cortex of effectively restricting early visual experience with oriented contours. J Neurophysiol. 1978 Jul; 41(4):896-909. Stryker MP, Sherk H, Leventhal AG, Hirsch HV. PMID: 681993.
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Ocular dominance columns and their development in layer IV of the cat's visual cortex: a quantitative study. J Comp Neurol. 1978 May 01; 179(1):223-44. LeVay S, Stryker MP, Shatz CJ. PMID: 8980725.
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Anatomical demonstration of orientation columns in macaque monkey. J Comp Neurol. 1978 Feb 01; 177(3):361-80. Hubel DH, Wiesel TN, Stryker MP. PMID: 412878.
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Orientation columns in macaque monkey visual cortex demonstrated by the 2-deoxyglucose autoradiographic technique. Nature. 1977 Sep 22; 269(5626):328-30. Hubel DH, Wiesel TN, Stryker MP. PMID: 409953.
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Quantitative study of cortical orientation selectivity in visually inexperienced kitten. J Neurophysiol. 1976 Jan; 39(1):63-70. Sherk H, Stryker MP. PMID: 1249604.
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Modification of cortical orientation selectivity in the cat by restricted visual experience: a reexamination. Science. 1975 Nov 28; 190(4217):904-6. Stryker MP, Sherk H. PMID: 1188372.
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Eye and head movements evoked by electrical stimulation of monkey superior colliculus. Exp Brain Res. 1975 Jul 11; 23(1):103-12. Stryker MP, Schiller PH. PMID: 1149845.
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Response characteristics of single cells in the monkey superior colliculus following ablation or cooling of visual cortex. J Neurophysiol. 1974 Jan; 37(1):181-94. Schiller PH, Stryker M, Cynader M, Berman N. PMID: 4204566.
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Saccadic and disjunctive eye movements in cats. Vision Res. 1972 Dec; 12(12):2005-13. Stryker M, Blakemore C. PMID: 4636124.
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Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey. J Neurophysiol. 1972 Nov; 35(6):915-24. Schiller PH, Stryker M. PMID: 4631839.
Michael Stryker earned his undergraduate degree in Philosophy and Mathematics from Deep Springs College and the University of Michigan before pursuing a PhD from Massachussetts Institute of Technology. He completed subsequent postdoctoral research at Harvard Medical School before joining the Physiology Department and Neuroscience program at UCSF.
Dr. Stryker holds the W.F. Ganong Endowed Chair of Physiology and is an elected member of the American Academy of Arts and Sciences as well as the US National Academy of Sciences.
Yujiao (Jennifer) Sun, Postdoctoral Fellow