
Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.
Projects:
Impact of ketone bodies on age-related inflammation and healthspan extension NIHK99AG058801Jan 1, 2019 - Dec 31, 2020 Role: Principal Investigator |
-
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 Jul 15. Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. PMID: 32838361.View in: PubMed Mentions:
-
How Inflammation Blunts Innate Immunity in Aging. Interdiscip Top Gerontol Geriatr. 2020; 43:1-17. Goldberg EL, Shaw AC, Montgomery RR. PMID: 32294641.
-
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nat Metab. 2020 Jan; 2(1):50-61. Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. PMID: 32694683.View in: PubMed Mentions:
-
Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Sci Immunol. 2019 11 15; 4(41). Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. PMID: 31732517.
-
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 12 03; 30(6):1024-1039.e6. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. PMID: 31735593.
-
Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metab. 2019 10 01; 30(4):621-623. Goldberg EL, Dixit VD. PMID: 31577929.
-
Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. J Physiol. 2019 08; 597(15):3885-3903. Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. PMID: 31206703.
-
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 10 05; 550(7674):119-123. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. PMID: 28953873.
-
Ã-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep. 2017 02 28; 18(9):2077-2087. Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. PMID: 28249154.
-
Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Mol Metab. 2017 02; 6(2):219-225. Goldberg EL, Dixit VD. PMID: 28180063.
-
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016 Feb 23; 14(7):1571-1580. Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. PMID: 26876170.
-
Editorial: "Crowning" eosinophils in adipose tissue: does location matter? J Leukoc Biol. 2015 Oct; 98(4):451-2. Goldberg EL, Dixit VD. PMID: 26429777.
-
Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol. 2015 Sep; 27(5):334-42. Camell C, Goldberg E, Dixit VD. PMID: 26776831.
-
Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015 May; 265(1):63-74. Goldberg EL, Dixit VD. PMID: 25879284.
-
The ketone metabolite Ã-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar; 21(3):263-9. Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. PMID: 25686106.
-
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell. 2015 Feb; 14(1):130-8. Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J. PMID: 25424641.
-
Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol. 2014 Jul 15; 193(2):757-63. Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. PMID: 24913978.
-
Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog. 2013 Sep; 9(9):e1003572. Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP. PMID: 24068921.
-
Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr). 2014 Feb; 36(1):199-212. Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. PMID: 23949159.