Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.
Impact of ketone bodies on age-related inflammation and healthspan extension NIHK99AG058801Jan 1, 2019 - Dec 31, 2020 Role: Principal Investigator
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