The goal of my laboratory is to understand the mechanisms by which the innate immune system coordinates metabolism in health and disease states. Over the last 8 years, my laboratory has been at the forefront of exploiting genetic tools to dissect the regulatory role of innate immune system in diet-induced obesity. We have performed pioneering work in this area, specifically on the mechanisms by which alternatively activated macrophages regulate glucose and lipid metabolism. While our initial efforts were focused on the importance of nuclear receptor signaling pathways in alternative macrophage activation, our recent efforts have focused on the upstream signaling pathways that direct alternative activation of macrophages in metabolic tissues. Another area my laboratory is studying is the mechanism by which the innate immune system coordinates tissue regeneration in health and disease states.
MD, University of Pennsylvania PhD, University of Pennsylvania BS in Biomedical Engineering, Johns Hopkins University