Markus Delling, PhD

Assistant Professor, UCSF School of Medicine

PhD in Neurobiology, Centre for Molecular Neurobiology (ZMNH), Hamburg, Germany
MSc in Chemistry and Biochemistry, University of Hamburg, Germany

Delling Lab

Featured Publications: 

Delling M*, Indzhykulian AA*, Liu X, Xie T, Corey DP, Clapham DE. Primary Cilia are not Calcium-Responsive Mechanosensors, 2016;531:656-60.

Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia, 2015;4:e11066.

Delling M*, DeCaen PG*, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-4. PMC4112737

DeCaen PG*, Delling M*, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013;504:315-8. PMC4073646

Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 2012;22:1149-62. PMC3397829

Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci USA. 2011;108:18114-9. PMC3207667

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome Nat Commun. 2010;1:38. PMC2928581

Dong X, Cheng X, Mills E, Delling M, Wang F, Kurz T , Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel, Nature. 2008;455:992-6.

Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J. Neurosci. 2008;28,8897-907.

Xu H*, Delling M*, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci USA. 2007;104,18321-6. PMC2084341

Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neurosci. 2006; 9, 628-35

Ramsey, I.S., Delling, M., and Clapham, D.E. An Introduction to TRP Channels. Annu Rev Physiol. 2006;68,619-47

Delling M. and Schachner M. The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells in Lipid Rafts in Biology and Medicine, Humana Press 2004Edited by Mattson, Mark, pp. 113-126

Sytnyk V., Leshchyns’ka I., Dityatev A., Delling M., and Schachner M. NCAM mediates accumulation of synaptic precursor organelles at nascent synapses J. Cell Biol. 2002;159,649-61

Delling, M., Wischmeyer, E., Dityatev, A., Sytnyk, V., Veh, RW., Karschin, A. and Schachner, M. The neural cell adhesion molecule NCAM regulates cell surface delivery of G protein-activated inwardly rectifying potassium channels via lipid rafts. J. Neurosci. 2002;22,7154-64

Niethammer, P*., Delling, M*., Sytnyk, V., Dityatev, A. and Schachner, M. Co-signaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J. Cell Biol. 2002;157,521-532

  1. Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016; 7:12109. PMID: 27357649.
    View in: PubMed
  2. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. PMID: 27007841.
    View in: PubMed
  3. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288; PMCID: PMC4112737.
    View in: PubMed, PubMed Central
  4. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289; PMCID: PMC4073646.
    View in: PubMed, PubMed Central
  5. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377; PMCID: PMC3631666.
    View in: PubMed, PubMed Central
  6. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. PMID: 22698280; PMCID: PMC3397829.
    View in: PubMed, PubMed Central
  7. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 1; 108(44):18114-9. PMID: 22025699; PMCID: PMC3207667.
    View in: PubMed, PubMed Central
  8. Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010; 1:38. PMID: 20802798.
    View in: PubMed
  9. Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H. Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem. 2009 Nov 13; 284(46):32040-52. PMID: 19638346; PMCID: PMC2797275.
    View in: PubMed, PubMed Central
  10. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16; 455(7215):992-6. PMID: 18794901; PMCID: PMC4301259.
    View in: PubMed, PubMed Central
  11. Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci. 2008 Sep 3; 28(36):8897-907. PMID: 18768683; PMCID: PMC4301590.
    View in: PubMed, PubMed Central
  12. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. PMID: 17989217; PMCID: PMC2084341.
    View in: PubMed, PubMed Central
  13. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. PMID: 16617338.
    View in: PubMed
  14. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. PMID: 16460286.
    View in: PubMed
  15. Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci. 2004 Oct 20; 24(42):9372-82. PMID: 15496673.
    View in: PubMed
  16. Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A. Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods. 2003 Nov 30; 130(1):65-73. PMID: 14583405.
    View in: PubMed
  17. Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 2002 Nov 25; 159(4):649-61. PMID: 12438412; PMCID: PMC2173095.
    View in: PubMed, PubMed Central
  18. Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M. The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci. 2002 Aug 15; 22(16):7154-64. PMID: 12177211.
    View in: PubMed
  19. Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H. What can we learn from explanted endovascular devices? Eur J Vasc Endovasc Surg. 2002 Aug; 24(2):117-22. PMID: 12389232.
    View in: PubMed
  20. Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32. PMID: 11980923; PMCID: PMC2173281.
    View in: PubMed, PubMed Central
  21. Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol. 1999 Sep 5; 40(3):343-55. PMID: 10440734.
    View in: PubMed

Markus Delling earned his Masters of Science in Chemistry and Biochemistry from University of Hamburg in Germany before pursuing a PhD in Neurobiology from the Centre for Molecular Neurobiology Hamburg (ZMNH). Afterwards, he spent time as a postdoctoral fellow with the Department of Cardiology at the Boston Children’s Hospital, Harvard Medical School and was a Pediatric Instructor of Cardiology at Boston Children’s Hospital before joining UCSF.